Inducible costimulator is essential for collagen-induced arthritis

Inducible costimulator is essential for collagen-induced arthritis.

CD4(+) helper Th cells play a major role in the pathogenesis of rheumatoid arthritis. Th cell activation, differentiation, and immune function are regulated by costimulatory molecules. Inducible costimulator (ICOS) is a novel costimulatory receptor expressed on activated T cells. We, as well as others, recently demonstrated its importance in Th2 cytokine expression and Ab class switching by B c...

Homologous Protein Costimulation by Blockade of Inducible Costimulator-B7 Amelioration of Collagen-Induced Arthritis

Involvement of Inducible Costimulator-B7

Collagen Antibody Induced Arthritis

Eupatilin Ameliorates Collagen Induced Arthritis

Eupatilin is the main active component of DA-9601, an extract from Artemisia. Recently, eupatilin was reported to have anti-inflammatory properties. We investigated the anti-arthritic effect of eupatilin in a murine arthritis model and human rheumatoid synoviocytes. DA-9601 was injected into collagen-induced arthritis (CIA) mice. Arthritis score was regularly evaluated. Mouse monocytes were dif...